Cytosoliic and nuclear ERK1/2 target-related papers

Cytosoliic and nuclear ERK1/2 target-related papers

Postby CellSigNet » Fri Jun 01, 2012 3:29 am

ATTENTION: Review Articles ONLY!!!

All literature about the cellular targets of ERK1/2 should be put here.

If you create the post, please indicate what kind of target it is:

1) Nuclear;
2) Cytosolic (indicate organelle/compartment location if known)
3) Shuttle-like

Thank You for cooperation :)
Posts: 16
Joined: Tue May 01, 2012 9:26 pm

Rb - nuclear

Postby CellSigNet » Fri Jun 01, 2012 3:32 am

Conserved RB functions in development and tumor suppression

Protein Cell 2011, 2(11): 864–878
Gabriel M. Gordon, Wei Du
Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA


The variety of human cancers in which the retinoblastoma protein pRb is inactivated reflects both its broad importance for tumor suppression and its multitude of cellular functions. Accumulating evidence indicates that pRb contributes to a diversity of cellular functions, including cell proliferation, differentiation, cell death, and genome stability. pRb performs these diverse functions through the formation of large complexes that include E2F transcription factors and chromatin regulators. In this review we will discuss some of the recent advances made in understanding the structure and function of pRb as they relate to tumor suppression, and highlight research using Drosophila melanogaster that reveals important, evolutionarily conserved functions of the RB family.

Pubmed link:
Posts: 16
Joined: Tue May 01, 2012 9:26 pm

Re: Cytosoliic and nuclear ERK1/2 target-related papers

Postby cicenasj » Thu Aug 02, 2012 10:10 am

This is one of the best reviews on targets:

Growth Factors. 2006 Mar;24(1):21-44.
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions.
Yoon S, Seger R.
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.


The extracellular signal-regulated kinase (ERK) cascade is a central pathway that transmits signals from many extracellular agents to regulate cellular processes such as proliferation, differentiation and cell cycle progression. The signaling via the ERK cascade is mediated by sequential phosphorylation and activation of protein kinases in the different tiers of the cascade. Although the main core phosphorylation chain of the cascade includes Raf kinases, MEK1/2, ERK1/2 (ERKs) and RSKs, other alternatively spliced forms and distinct components exist in the different tiers, and participate in ERK signaling under specific conditions. These components enhance the complexity of the ERK cascade and thereby, enable the wide variety of functions that are regulated by it. Another factor that is important for the dissemination of ERKs' signals is the multiplicity of the cascade's substrates, which include transcription factors, protein kinases and phosphatases, cytoskeletal elements, regulators of apoptosis, and a variety of other signaling-related molecules. About 160 substrates have already been discovered for ERKs, and the list of these substrates, as well as the function and mechanism of activation of representative substrates, are described in the current review. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Understanding of these processes may provide a full picture of the distinct, and even opposing cellular processes that are regulated by the ERK cascade.

PMID: 16393692
User avatar
Posts: 41
Joined: Wed Jul 13, 2011 1:31 am
Location: Bern

Re: Cytosoliic and nuclear ERK1/2 target-related papers

Postby CellSigNet » Tue Feb 19, 2013 8:31 am

FASEB J. 2000 Nov;14(14):2147-57.
Control of the eukaryotic cell cycle by MAP kinase signaling pathways.
Wilkinson MG, Millar JB.


In an often rapidly changing environment, cells must adapt by monitoring and reacting quickly to extracellular stimuli detected by membrane-bound receptors and proteins. Reversible phosphorylation of intracellular regulatory proteins has emerged as a crucial mechanism effecting the transmission and modulation of such signals and is determined by the relative activities of protein kinases and phosphatases within the cell. These are often arranged into complex signaling networks that may function independently or be subject to cross-regulation. Recently, genetic and biochemical analyses have identified the universally conserved mitogen-activated protein (MAP) kinase cascade as one of the most ubiquitous signal transduction systems. This pathway is activated after a variety of cellular stimuli and regulates numerous physiological processes, particularly the cell division cycle. Progression through the cell cycle is critically dependent on the presence of environmental growth factors and stress stimuli, and failure to correctly integrate such signals into the cell cycle machinery can lead to the accumulation of genetic damage and genomic instability characteristic of cancer cells. Here we focus on the MAP kinase cascade and discuss the molecular mechanisms by which these extensively studied signaling pathways influence cell growth and proliferation.

PMID: 11053235
Posts: 16
Joined: Tue May 01, 2012 9:26 pm

Re: Cytosoliic and nuclear ERK1/2 target-related papers

Postby kenedy » Sun Nov 27, 2016 10:23 am

Great post you have shared here.well done
Posts: 1
Joined: Sun Nov 27, 2016 10:18 am

Return to Literature recommendations

Who is online

Users browsing this forum: No registered users and 1 guest